Table 1.
Mendelian loci for Parkinson’s disease
| Locus | Inheritance | Onset | Gene | Function |
|---|---|---|---|---|
| PARL1/4 | Dominant | 30–70 | SNCA | Vesicle fusion |
| PARK2 | Recessive | Teens | PKRN | Mitophagy |
| PARK6 | Recessive | Teens | PINK1 | Mitophagy |
| PARK7 | Recessive | Teens | DJ1 | Mitophagy |
| PARK8 | Dominant | 50–70 | LRRK2 | Autophagy control? |
| PARK9 | Recessive | Teens | ATP13A2 | Lysosomes |
| PARK14 | Recessive | Teens | PLA2G6 | Not clear |
| PARK15 | Recessive | Teens | FBX07 | Mitophagy |
| PARK17 | Dominant | 50–70 | VPS35 | Endosomes |
| PARK19 | Recessive | Young | DNAJC6 | Endosomes |
| PARK20 | Recessive | Teens | SYNJ1 | Endosomes |
| PARK21 | Dominant | 30–70 | DNAJC13 | Endosomes |
| Unassigned | X-linked | 30–50 | RAB39B | Not clear |
| Unassigned | High risk | 30–70 | GBA | Lysosomes |