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. 2019 Jul 29;68(12):2195–2205. doi: 10.1136/gutjnl-2019-318882

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Further evaluation of the 5hmC-based diagnostic model. (A) The performance of the wd-scores or AFP in distinguishing HCC from controls is shown for the independent validation set 2. (B) For those patients with confirmed stages, the performance of the wd-scores or AFP in distinguishing early or late HCC from controls is shown for validation set 2. (C) The boxplots show the relationships between wd-scores and the clinical diagnosis across the training set and both validation sets. Control: healthy individuals and patients with benign liver lesions. AFP, α-fetoprotein; AUC, area under curve; CHB, chronic hepatitis B virus infection; HCC, hepatocellular carcinoma; 5hmC, 5-hydroxymethylcytosines; LC, liver cirrhosis; wd-score, weighted diagnostic score.