Figure 7.

Histopathologic and laser confocal microscopic evaluation of cysteine cathepsins in colorectal cancer. Representative histology and fluorescence confocal microscopy of the tumors in APC^LoxP/LoxPMsh2^LoxP/LoxP mice confirms the results of in vivo optical imaging with demonstration of neoplastic cells within different layers of the colon wall with significantly higher fluorescence signal compared to the normal adjacent colon tissue (A), and high expression of cysteine cathepsins S, K, L and B compared to the adjacent normal colon tissue (B).