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. 2019 Nov 15;13:1234. doi: 10.3389/fnins.2019.01234

FIGURE 4.

FIGURE 4

Representative double labeling immunofluorescence images of LDH-A with M/L-opsin in wild-type (WT) mouse retina and in Rd1 mouse retinas from postnatal day (P) 14 to P60. (A–C) In WT retinas, LDH-A is associated with rod and cone photoreceptor somas, inner segments and axonal terminals, together with cells in the inner retina. (D–F) At P14, hexokinase II colocalizes with M/L-opsin in shrunken inner segments (arrow) and weakly labels photoreceptor somas and axonal terminals. (G–L) From P30 to P60, the ONL comprises a single layer of surviving cones largely devoid of segments. LDH-A is observed in surviving cone somas (arrows). All images were captured from the superior retina, which comprises primarily M/L-cones. INL, inner nuclear layer; IS, inner segments, ONL, outer nuclear layer; RPE, retinal pigment epithelium. Scale bar: 20 μm.