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. 2019 Nov 15;13:1234. doi: 10.3389/fnins.2019.01234

FIGURE 9.

FIGURE 9

Representative double labeling immunofluorescence images of ubiquitous mitochondrial creatine kinase (CK-MT1A) with S-opsin in wild-type mouse retina and Rd1 mouse retinas from postnatal day (P) 7 to P60. In WT retinas (A–C) and at P7 (D–F), CK-MT1A colocalizes with S-opsin in photoreceptor inner segments, cone somas, and axonal terminals. At P14, the ONL is dramatically reduced in thickness. CK-MT1A colocalizes with S-opsin in shrunken inner segments, cone somas, and axonal terminals (G–I). From P21 onward, the ONL is reduced to a single layer of surviving cones largely devoid of segments. CK-MT1A expression within S-opsin-positive cone somas and axonal terminals persists at all time points (J–R). All images were captured from the inferior retina, which comprises primarily S-cones. INL, inner nuclear layer; IS, inner segments; ONL, outer nuclear layer. Scale bar: 20 μm.