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. 2019 Nov 15;9:1236. doi: 10.3389/fonc.2019.01236

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Copyright © 2019 Guven-Maiorov, Tsai and Nussinov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structural HMI networks. (A) Structural HMI network for all known oncoviruses. Most of the targets of viral proteins are unique, but there are also some common ones (central part) across different viruses. Human proteins are shown as gray circular nodes and oncoviral proteins are blue diamond-shaped nodes. (B–I) Structural HMI networks for individual oncoviruses. Viruses can target the same host protein with more than 1 of its proteins (middle parts of the circles: some host proteins are common targets to more than 1 protein).