Table 2.

Association results of the replicated SNP rs79237970 in the CTD and HCTZ treated (A) and βB treated (B) African American participants.

SNP	CHR	A1	MAF	DISCOVERY PEAR-2 Chlorthalidone		REPLICATION PEAR1 Hydrochlorothiazide		Meta-Analysis (PEAR-2 and PEAR)
				β	P-value	β	P-value	β	P-value
(A) Association of rs79237970 with DBP in CTD and HCTZ treated African American participants
rs79237970	2	T	0.013	−15.75	5.76 × 10−6	−9.815	0.0004	−12.02	8.49 × 10−9
(B) Association of rs79237970 with DBP in βB treated African American participants
SNP	CHR	A1	MAF	PEAR-2 Metoprolol		PEAR Atenolol		Meta-Analysis (PEAR-2 and PEAR)
				β	P-value	β	P-value	β	P-value
rs79237970	2	T	0.013	7.47	9.9 × 10−3	4.36	0.04	5.6	1.5 × 10−3

CHR: chromosome; A1: Effect Allele; MAF: Minor Allele Frequency; β: regression coefficient for Effect Allele; DBP: Diastolic

Blood Pressure; CTD: Chlorthalidone; HCTZ: Hydrochlorothiazide.