Table 10.

Pediatric CNS disease: Included studies evaluating the use of RT for LMD.

References	Study type	Study Pop with LMD (n)	Treatment era (years)	Median age, years	Treatment	Median OS (months)	Conclusions
Kandt et al. (79)	Obs	6	1977–1982	9	67% FSRT; 17% C; 17% BSC	7	RT is beneficial
Ray et al. (80)	Obs	22	2004–2012	5	100% FSRT	NYR	Durable response can be achieved with proton RT
Wei et al. (81)	Obs	6	2007–2012	6.5	100% WBRT; 17% CSI; 17% SRS	NR	Salvage CSI is effective

RT, radiotherapy; LMD, leptomeningeal disease; Pop, population; Obs, observational study; PP, practice patterns; NR, not reported; BSC, best supportive care; C, chemotherapy alone; ITC, intrathecal chemotherapy; WBRT, whole brain radiotherapy; FSRT, spine RT; CSI, craniospinal RT; SRS, stereotactic radiosurgery; NYR, not yet reached; PFS, progression free survival.