Table 11.

Pediatric rhabdomyosarcoma: Included studies evaluating the use of RT for LMD.

Reference	Study type	Study Pop with LMD (n)	Treatment era (years)	Median age, years	Treatment	Median OS (months)	Conclusions
De et al. (82)	Obs	21	1999–2016	15	48% CSI; 14% C; 19% WBRT; 5% ITC; 14% surgery; 5% SRS	5	Conformal RT techniques, such as proton CSI, may help limit overlap of RT fields and reduce toxicities

RT, radiotherapy; LMD, leptomeningeal disease; Pop, population; Obs, observational study; PP, practice patterns; NR, not reported; BSC, best supportive care; C, chemotherapy alone; ITC, intrathecal chemotherapy; WBRT, whole brain radiotherapy; FSRT, spine RT; CSI, craniospinal RT.