Table 8.

Gynecologic cancer: Included studies evaluating the use of RT for LMD.

References	Study type	Study Pop with LMD (n)	Treatment era (years)	Median age, years	Treatment	Median OS (months)	Conclusions
Teckie et al. (76)	Obs	12	1996–2010	56.1	58% WBRT; 8% partial brain RT;17% FSRT; 8% C; 8% BSC	3.6	RT leads to partial or complete response of LMD, but will likely recur or progress
Asensio et al. (77)	Obs	3	2000	63	33% ITC; 100% FSRT; 33% WBRT; 33% C	NR	CSF evaluation may not be sufficient for diagnosis Improving diagnosis may improve outcomes

RT, radiotherapy; LMD, leptomeningeal disease; Pop, population; Obs, observational study; PP, practice patterns; NR, not reported; BSC, best supportive care; C, chemotherapy alone; ITC, intrathecal chemotherapy; WBRT, whole brain radiotherapy; FSRT, spine RT; CSI, craniospinal RT.