Table 3.
Median (range) for gastric mucosal lesions identified on endoscopy for 24 healthy research dogs administered placebo, clopidogrel with placebo, prednisone with placebo, or combination prednisone and clopidogrel for 28 days
| Baseline | Day 14 | Day 28 | |
|---|---|---|---|
| Placebo | |||
| Hemorrhages | 24 (2‐57) | 1 (0‐13) | 2 (0‐38) |
| Punctate erosions | 1 (0‐4)D | 1 (0‐69)BCD | 0 (0‐5)CD |
| Invasive erosions | 0 (0‐1)B,χ | 0 (0‐203)B,α | 0 (0‐3)B,β |
| Ulcers** | 0 (0‐0) | 0 (0‐0) | 0 (0‐0) |
| Clopidogrel | |||
| Hemorrhages | 0 (0‐1) | 1 (0‐6) | 0 (0‐1) |
| Punctate erosions | 0 (0‐9)D | 3 (1‐24)ABC | 0 (0‐14)D |
| Invasive erosions | 0 (0‐1)B,χ | 1 (0‐22)B,α | 0 (0‐0)B,β |
| Ulcers** | 0 (0‐0) | 0 (0‐0) | 0 (0‐0) |
| Prednisone | |||
| Hemorrhages | 1 (0‐63) | 0 (0‐62) | 0 (0‐39) |
| Punctate erosions | 0 (0‐7)D | 49 (7‐228)A | 32 (8‐308)A |
| Invasive erosions | 0 (0‐4)A,χ | 27 (0‐168)A,α | 18 (0‐279)A,β |
| Ulcers** | 0 (0‐0) | 0 (0‐2) | 0 (0‐2) |
| Prednisone & Clopidogrel | |||
| Hemorrhages | 0 (0‐34) | 0 (0‐12) | 4 (0‐70) |
| Punctate erosions | 1 (0‐9)CD | 30 (1‐236)A | 19 (90‐110)A |
| Invasive erosions | 0 (0‐9)A,χ | 24 (0‐227)A,α | 15 (0‐40)A,β |
| Ulcers** | 0 (0‐0) | 1 (0‐6) | 0 (0‐0) |
Note: Values that do not share a common superscript letter differed significantly (P < .05) based on treatment‐by‐time or treatment interactions based on posthoc analysis. Values that do not share a Greek letter differed significantly (P < .05) among time points based on posthoc analysis. **Statistical comparisons were not performed because of limited occurrences based on posthoc analysis.