Table 1.
Median and interquartile range (IQR) data for blood glucose and insulin in healthy newborn foals administered glucose orally (300, 500, and 1000 mg/kg) and IV (300, 500, and 1000 mg/kg), lactose (1000 mg/kg), and fasted
| Group/Time | 0 min | 5 min | 30 min | 120 min | 180 min | 210 min |
|---|---|---|---|---|---|---|
| Glucose (mg/dL) | ||||||
| OGT‐300 | 159.5 (153.5‐183.8) | 166 (150.3‐181.0) | 174.5 (151.5‐179.3) | 150 (135‐160) | 140 (136‐146.5)** | 192 (147‐251) |
| OGT‐500 | 120.5 (97‐169.5) | 124(113‐169) | 138.5 (133.5‐171.3) | 116.5 (105.3‐142.8) | 115.5 (85.8‐151) | 123 (116‐232) |
| OGT‐1000 | 135 (116.3‐159.8) | 134.5 (126‐159.3) | 152 (122‐179) | 148 (135.3‐155.5) | 110 (97‐166) | 210 (183‐226)^ |
| IVGT‐300 | 150 (135.5‐180.5) | 240 (235‐266.5)** | 131 (118.5‐151.5) | 139 (121.5‐154.5) | 138 (122‐149) | ‐ |
| IVGT‐500 | 138 (130‐172.5) | 296 (262‐362.5)** | 168 (132‐179) | 121 (119‐133) | 121 (114‐136) | 172 |
| IVGT‐1000 | 118 (105.5‐130.5) | 432 (408‐459.5)** | 195 (189.5‐254.5) | 114 (106.5‐133) | 120 (114.5‐124.5) | 212 (196‐224)^ |
| OLT | 126.5 (119.8‐161.5) | 140 (131.8‐160) | 197.5 (163.8‐207.5)* | 119.5 (116.8‐165) | 119.0 (113‐131) | 238 (214.3‐255.5)^ |
| Fasted | 139.5 (125‐145.3) | 128 (118‐137.5) | 115 (104.5‐145.8) | 112.5 (91.8‐119.3)* | 108 (83.8‐122)** | 191.5 (125‐253.5)^ |
| Insulin (μIU/mL) | ||||||
| OGT‐300 | 9.75 (5.9‐19.4) | 11.0 (6.0‐19.2) | 13.2 (9‐21.2) | 6.3 (2.4‐10.3)** | 6.1 (2.7‐10.7) | 31.6 (15.3‐64.0)^ |
| OGT‐500 | 14.4 (8.5‐26.5) | 9.6 (4.2‐19.0) | 12.5 (7.5‐19.9) | 6.0 (2.3‐21.7) | 6.2 (1.6‐15.2) | 13.9 (4.9‐43.10) |
| OGT‐1000 | 7.6 (3.0‐23.2) | 11.2 (3.8‐21.7) | 8.8 (4.1‐27.3) | 5.6 (2.3‐8.4) | 5.5 (1.2‐19.8) | 59.5 (31.3‐102.1)^ |
| IVGT‐300 | 6.0 (3.7‐13.5) | 51.3 (35.5‐56.7)* | 5.9 (4.4‐10.2) | 4.0 (2.8‐9.7) | 6.9 (1.5‐10.1) | ‐ |
| IVGT‐500 | 14.7 (7.6‐23.3) | 60.2 (54.8‐96.9)* | 11.7 (7.8‐22.3) | 7.0 (2.4‐10.3) | 4.7 (2.2‐11.7) | 23.2 |
| IVGT‐1000 | 2.4 (1.0‐10.0) | 78.5 (51.8‐166.2)** | 33.2 (12.2‐67.2) | 4.2 (2.0‐7.1) | 3.4 (0.9‐6.8) | 72.2 (30.7‐140.2)^ |
| OLT | 11.8 (9.8‐31.5) | 31.4 (12.1‐58.3) | 38.1 (26.0‐51.5) | 8.7 (5.9‐16.5) | 12.4 (8.4‐13.3) | 66.3 (25.6‐115.8)^ |
| Fasted | 18.3 (10.4‐53.5) | 13.9 (8.5‐46.4) | 7.6 (5.7‐25.2) | 7.3 (3.5‐10.4)** | 6.1 (3.5‐7.6)** | 48.6 (23.7‐85.9)^^ |
Abbreviations: Fasted, no oral or IV treatment; IVGT‐300, 300 mg/kg of glucose; IVGT‐500, 500 mg/kg of glucose; IVGT‐1000, 1000 mg/kg of glucose; OGT‐300, 300 mg/kg of glucose; OGT‐500, 500 mg/kg of glucose; OGT‐1000, 1000 mg/kg of glucose; OLT, 1000 mg/kg of lactose.
*P < .05, **P < .01 compared to time 0; ^P < .05, ^^P < .01 compared to time 180 minutes.