Table 3.
Median and interquartile range (IQR) data for area under the curve (AUC) for glucose (AUC‐glucose), insulin (AUC‐insulin), GIP (AUC‐GIP), and GLP‐1 (AUC‐GLP‐1) in healthy newborn foals administered glucose orally (300, 500, and 1000 mg/kg) and IV (300, 500, and 1000 mg/kg), lactose (1000 mg/kg)
| Glucose (mg*min/dL) | Insulin (μIU*min/mL) | GIP (pg*min/mL) | GLP‐1 (pmol*min/L) | |
|---|---|---|---|---|
| OGT‐300 | 461.5 (418.7‐497.9)** | 29.1 (17.3‐35.1) | 466.9 (227.1‐723.7) | 402.8 (291.7‐698.6) |
| OGT‐500 | 379.5 (347.2‐493.8) | 32.6 (24.6‐51.7) | 1285 (616.9‐1771) | 373.6 (133.2‐798.8) |
| OGT‐1000 | 453 (402‐520.8) | 32.7 (23.7‐43.8) | 433 (247.2‐1204) | 161.6 (100.9‐421.2) |
| IVGT‐300 | 444.9 (375.7‐462)* | 24.2 (15.8‐45.4) | 157.9 (142.1‐350.2) | 199.3 (154.4‐385.4) |
| IVGT‐500 | 419 (383.1‐460.6) | 31.3 (21.3‐53.2) | 340.5 (194.6‐545.3) | 223.2 (171.9‐803) |
| IVGT‐1000 | 439.4 (430.9‐517.1)* | 42 (21.8‐86.4) | 167 (164.8‐292.9) | 175.5 (65‐486.1) |
| OLT | 417.5 (404.8‐527.3) | 57.2 (50.5‐87.2)* | 577.9 (414.7‐998.7) | 138.8 (91.4‐255) |
| Fasted | 344.2 (300.9‐376.4) | 25.2 (16‐44.6) | 547.7 (215.3‐1912) | 266.4 (143.7‐460.1) |
Abbreviations: Fasted, no oral or IV treatment; GIP, glucose‐dependent insulinotropic polypeptide; GLP‐1, glucagon‐like peptide‐1; IVGT‐300, 300 mg/kg of glucose; IVGT‐500, 500 mg/kg of glucose; IVGT‐1000, 1000 mg/kg of glucose; OGT‐300, 300 mg/kg of glucose; OGT‐500, 500 mg/kg of glucose; OGT‐1000, 1000 mg/kg of glucose; OLT, 1000 mg/kg of lactose.
*P < .05, compared to fasted foals; **P < .01 compared to fasted foals.