Figure 2.

Melatonin target proteins and melatonin concentrations. Melatonin target proteins are positioned on the log scale of molar melatonin concentrations according to their affinity/efficacy for melatonin. The range of melatonin concentrations measured in biological fluids and tissues are indicated on the same scale. Legend for melatonin target proteins: black letters, demonstrated direct targets; red letters, suggested direct targets (docking, functional studies); bold letters, findings were independently replicated; green background, co-crystal structures with melatonin or phenyl-melatonin available. Calret, calreticulin; GIT, gastrointestinal tract; MLT, melatonin; PR, pineal recess; SA, serum albumin.