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. 2019 Nov 21;9:17324. doi: 10.1038/s41598-019-54020-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bland-Altman plot of the differences between tidal volume measured by the turbine driven ventilator and the lung simulator in the obstructive condition. Data are reported in ml. PEEP: Positive end expiratory pressure (values are expressed in cmH₂O).TDV: tidal volume (V_T) measured by turbine driven ventilator; LS: Tidal volume (V_T) measured by lung simulator. Average (x-axys): average of the two measurements; TDV – LS (y-axys): difference between mesurements. Bias: Average of the differences between measurements. 95% LoA: Limits of agreement (±1.96 standard deviation - SD - of the bias). In this plot, the overall bias is 141 ml, and 95% LoA are from 109 to 173 ml. Although all plotted differences are within the 95% LoA, a large clinical relevance bias is found at all tested PEEP levels.