Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 21;10(12):881. doi: 10.1038/s41419-019-2120-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — JQ1-sensitive cell demonstrated a distinct expression signature characterized by overexpression of LGR5, PTEN and OLIG2 (a, see also Table S2). Distinct sensitivity signature is highly enriched among TCGA patient samples classified as proneural GBM (b). Pathway analysis showed enrichment of genes regulating cell cycle, DNA replication and transcription (c). JQ1-sensitive cells were enriched in genes regulated by MYC and involved in DNA repair, while JQ1-resistant cells were enriched in genes regulating EMT, hypoxia, and p53, TGFβ and TNFα signaling (d). OLIG2 expression correlates (Pearson correlation) with the sensitivity to JQ1 inhibition (e) and high expression of OLIG2 was confirmed by immunoblotting (f). Values above the blot represent relative quantification normalized to ACTIN and U3005MG. Similar to OLIG2, the expression of LGR5 correlates (Pearson correlation) with the JQ1 sensitivity (g) and the expression of LGR5 was confirmed by real-time quantitative PCR (h).