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. 2019 Nov 21;10:5277. doi: 10.1038/s41467-019-13142-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Effects of CaMKII inhibition on [Ca²⁺]_mito-to-[Ca²⁺]_cyto coupling. a Heatmaps of [Ca²⁺]_cyto and [Ca²⁺]_mito activities in dendrites and somas with KN93 and KN92 treatment. Vertical dashed lines partition records obtained in the pre-run, run, and post-run stages. Each row represents Ca²⁺ activity from a dendrite (55 dendrites in KN93 group; 48 dendrites in KN92 group) or a soma (48 somas in KN93 group; 48 somas in KN92 group). Pairs of [Ca²⁺]_cyto and [Ca²⁺]_mito activities were sorted by time of maximum response of [Ca²⁺]_cyto activity. Scale bars: 20 s. b–e Effect of CaMKII inhibitors on [Ca²⁺]_cyto and [Ca²⁺]_mito transient frequency before, during and after running on treadmill in dendrites (b, d) and somas (c, e). n = 4–5 mice. 100 μM KN62, 100 μM KN93, 100 μM KN92 (inactive analog of KN93) in ACSF, or ACSF were administrated on the brain with flapped skull for 20 min before imaging. f, g Effect of CaMKII inhibitors on [Ca²⁺]cyto amplitude in dendrites (f) and somas (g) before and during running. n = 4–5 mice. h, i CaMKII inhibition decreased coupling fidelity in dendrites (h) and somas (i). Data are presented as mean ± SEM. *P < 0.05. **P < 0.01. ***P < 0.0001, by one-way ANOVA and multiple comparisons. Source data are provided as a Source Data file.