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. 2019;10(5-6):119–133. doi: 10.18632/genesandcancer.197

Figure 1. PCI34051 decreases U87 and T98G viability.

Figure 1

A. and B. Cell viability determined by CCK-8 assay after treatment with 30 and 40 µM PCI34051 for 4 days. C. T98G cell viability determined with the CCK-8 assay after 3 days’ treatment with either 30 µM PCI34051 or 250 µM TMZ. n = 3 *p < 0.05, **p < 0.005. D. T98G cell (Empty vector or TRCN0000350469 shHDAC8) viability determined with the CCK-8 assay after 4 days’ treatment with 250 µM TMZ. E. Extracts of U87 and T98G cells expressing empty vector (EV) or shHDAC8 (1- TRCN0000350469, 2-TRCN0000004852 and 3-TRCN0000314874) were subject to Western blotting with tubulin and HDAC8 antibodies.