Figure 2.

Relation between drug targets, non-drug targets and diseases associations. Panel A shows the fraction of the drug targets among proteins associated with a given minimal number of diseases K. Panel B is a Venn diagram that visualizes overlap between the disease associated proteins (with K = 1 and K = 13), the drug targets (dataset D; green border), and the non-drug targets (dataset N; red border). Among the non-drug targets we define the Nn dataset of non-druggable proteins (brown area), i.e., the non-drug targets that are not associated with any disease, and the Nd dataset of possibly druggable proteins (orange area), i.e., the non-drug targets that are associated with 13 or more diseases.