Table 2.

Weighted set of significantly enriched GO terms and pathways for genes commonly associated with bipolar disorder and BMI.

	Gene set size	Overlap	Enrichment ratio	p	FDR	Included genes
GO terms
Neuronal cell body	486	29	2.08	1.0E−04	0.025	CAD, CHRNA3, CRTC1, CYP17A1, DDN, DGKI, DRD2, EEF1A2, FXR2, GNAT1, GNRH1, GRIK5, HPCA, ITPR3, KCNN2, KIF5A, KLC1, MAPK1, NRXN1, PARD3, PDE1C, PSEN1, RPTOR, RTN4, RTN4RL1, SLC1A3, SLC4A10, UCHL1, SHTN1
Pathways
Hemostasis	620	38	2.25	2.1E−06	0.004	AK3, AKAP10, ALDOA, ATP2A1, ATP2A2, ATP2B2, CBX5, CDC37L1, CSK, DAGLA, DGKG, DGK1, ECM1, ITGAL, ITGB3, ITIH3, ITIH4, ITPR3, KIF5A, KLC1, MAPK1, MAPK3, MFN2, NEF2, OLA1, PDE3B, PLCG1, PPIL2, PRKACA, SH2B1, SLC7A6, SLC8A1, TUBA1A, TUBA1B, TUBA1C, TUBA4A, VCL, ZFPM2
Signaling by Hedgehog	147	14	3.50	4.8E−05	0.020	ADCY9, DERL2, IFT172, IFT57, PRKACA, PSMA5, PSMB10, RPGRIP1L, SUFU, TUBA1A, TUBA1B, TUBA1C, TUBA4A, ULK3
L1CAM interactions	117	12	3.76	8.1E−05	0.020	ITGB3, KCNQ2, MAP2K1, MAPK1, MAPK3, NCAM1, RPS6KA5, SHTN1, TUBA1A, TUBA1B, TUBA1C, TUBA4A
Signaling by BRAF and RAF fusions	60	8	4.89	0.0002	0.030	CSK, ITGB3, MAP2K1, MAPK1, MAPK3, MARK3, QKI, VCL

Enriched GO terms and REACTOME pathways were obtained using the weighted set cover method implemented by WebGestalt, which reduces redundancy of the gene sets

BMI body mass index, FDR false discovery rate