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. 2019 Nov 21;9:17291. doi: 10.1038/s41598-019-53756-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bifunctional CARs and TCRs with two ligand binding domains. (a) FACS plot of transfected Jurkat cells stained for binding to NY-ESO-1 pMHC tetramer (y-axis) and MAGE-A3 pMHC tetramer (x-axis). M refers to MAGE-A3 and N refers to NY-ESO-1. (b) NFAT-luciferase signal of transfected Jurkat cells after 6hrs of co-culture with NY-ESO-1 (left) and MAGE-A3 (right) peptide-loaded T2 cells. The error bars indicate SD (n = 2). (c) Schematics of the constructs tested. M refers to MAGE-A3 and N refers to NY-ESO-1. (d) Same as (b).