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. 2019 Nov 21;5:27. doi: 10.1038/s41526-019-0088-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Euclidean and Angular distances in gene-expression patterns. The plot reports the Euclidean distance (see also Supplementary Fig. 3) from the centre computed over the gene-expression values (concentric circles) and the angle of deviation (the angle between OG1 and different profiles having Pearson r with OG1 as cosine) from baseline (OG1) condition. Data are computed at different times for both RMPCLUM and RPMAD (1, 2, 6, 24 h). The overlapping or partially overlapping experimental points are the following: OG6, OG24, RPMA1, RPMA6, RPMC1, RPMC6, RPMC24.