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. 2019 Nov 21;10(12):878. doi: 10.1038/s41419-019-2115-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Strategy for generating vFlip^AlbCre+ mice. b Percentage of viable mice per genotype observed at 3-weeks of age in correlation to the expected Mendelian ratio. c Kaplan-Meyer survival analysis of vFlip^AlbCre+ (n = 11) versus control (n = 13) mice starting from birth. d–g Analysis of vFlip^AlbCre+ mice and control littermates. d Picture of neonates and neonatal liver (80 h). Scale bar: 10 mm and 5 mm. e Serum Aspartate aminotransferase (AST) and Alkaline Phosphatase (AP) concentration. f Quantification of relative mRNA expression of Inos in the liver of embryonal (E20; n = 3/group) and neonatal (4 h post birth; n = 4/group) mice. g Representative H&E stainings of liver cross-sections at indicated time points post birth. Scale bar 500 µm. Gene expression levels are shown relative to Hprt. Error bars indicate ± SD, **P < 0.01, ***P < 0.001, ****P < 0.0001 by unpaired two-tailed t-test, intergroup comparison was performed via one-way ANOVA analysis.