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. 2019 Sep 11;4(5):596–610. doi: 10.1016/j.jacbts.2019.04.005

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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PhosphoACC Regulates TG Lipid Species in Platelets of CAD Patients

(A, B) Volcano plot representations of the 865 lipid species detected in platelets by lipidomic profiling. Log fold-changes and p values were calculated from the multivariate regression model. Lipids above the horizontal dotted line were up- or down-regulated with significant adjusted p values. Relationship among (A) diabetic status and plasma triglyceride (TG) levels and (B) platelet phosphoACC and intraplatelet lipid species content. (C) Class enrichment analysis of fatty-acid-chain constituents of TG lipid species in platelets with respect to increased phosphoACC. Bars (dark gray) represent the percentage of down-regulated fatty acid-containing TG. Odds ratio (OR) and adjusted p values derived from Fisher’s exact test are shown. CE = cholesterol ester; CI = confidence interval; DAG = diacylglycerol; FFA = free fatty acid; LPC = lysophosphatidylcholine; LPE = lysophosphatidylethanolamine; OR = odds ratio; PC = phosphatidylcholine; PE = phosphatidylethanolamine; PEO = plasmenyl phosphatidylethanolamine; PEP = plasmalogen phosphatidylethanolamine; SM = sphingomyelin; other abbreviations as in Figure 3.