Figure 3.

Inhibition of Endothelial NOS Eliminates the Beneficial Effect of CMEC on CM Contraction and Relaxation

(A) Inhibition of CMEC nitric oxide (NO) generation with N(ω)-nitro-L-arginine methyl ester (L-NAME) abrogated the effect of CMECs on CM sarcomere shortening, (B) return velocity, and (C) tau. (A to C) Graphs representing single CMs isolated from 1 individual rat, distributed into the 3 corresponding experimental conditions; 40 to 45 CMs were measured per condition. Data are representative of 3 independent experiments. Data are represented as mean ± SD. NOS = nitric oxide synthase; other abbreviations as in Figures 1 and 2.