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. 2019 Nov 21;9:17309. doi: 10.1038/s41598-019-54032-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CSF GAP-43 differs across disease groups and correlates with EDSS: (A) CSF GAP-43 concentrations across disease groups in the MS population and HCs. **p = 0.0054, ***p < 0.0004. (B) Correlation between CSF GAP-43 concentration and EDSS in MS patients, p < 0.001. CSF, cerebrospinal fluid; GAP-43, growth-associated protein 43; MS, multiple sclerosis; HCs, healthy controls; RRMS, relapsing-remitting multiple sclerosis; PPMS, primary progressive multiple sclerosis; EDSS, Expanded Disability Status Scale.