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. 2019 Nov 21;9:17309. doi: 10.1038/s41598-019-54032-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CSF GAP-43 and clinical characteristics: (A) CSF GAP-43 concentrations in RRMS patients with a relapse within 3 months prior to CSF sampling compared to CSF obtained in remission, p < 0.01. (B) CSF GAP-43 concentrations at baseline in MS patients with gadolinum-enhancing MRI lesions compared to those without lesions, p = 0.088. CSF, cerebrospinal fluid; GAP-43, growth-associated protein 43; RRMS, relapsing-remitting multiple sclerosis; MS, multiple sclerosis; MRI, magnetic resonance imaging.