Effect of the reference compound and different nicotine-containing products on MAO-B activity. A) Reference compound pargyline hydrochloride; B) snus extracts from CRP1.1, GCW, and TAXI; C) e-liquid; D) AE from 3R4F, THS 2.2, and MESH 1.1; E) GVP extracts from 3R4F, THS 2.2, and MESH 1.1; and F) TPM from 3R4F, THS 2.2, and MESH 1.1. Data are expressed as mean ± standard deviation (A, B, C, E) or 95 % confidence interval (D, F) derived from three experiments. AE, aqueous extracts; GVP, gas–vapor phase; TPM, total particulate matter.