Table 1.
All N = 150 | No obstructive CAD N = 63 | Obstructive CAD N = 87 | P value* | |
---|---|---|---|---|
Demographics | ||||
Age in years | 67.6 (11.5) | 66 (10.39) | 68 (12.23) | 0.470 |
Male sex | 96 (64%) | 29 (48%) | 67 (74%) | 0.001 |
BMI | 28.1 (5.4) | 28.7 (6.3) | 26.9 (4.6) | 0.291 |
Medical history | ||||
History of CVD | 111 (74%) | 41 (68%) | 70 (78%) | 0.196 |
History of CAD | 25 (17%) | 3 (5%) | 22 (24%) | 0.002 |
History of MI | 18 (12%) | 2 (3%) | 16 (18%) | 0.008 |
History of PAD | 10 (7%) | 3 (5%) | 7 (8%) | 0.504 |
Diabetes mellitus | 35 (23%) | 14 (23%) | 21 (23%) | 0.575 |
Hypertension | 97 (65%) | 36 (60%) | 61 (68%) | 0.329 |
Dyslipidemia | 87 (58%) | 37 (62%) | 50 (56%) | 0.458 |
Current smoker | 39 (26%) | 15 (25%) | 24 (27%) | 0.820 |
Family history of CAD | 45 (30%) | 19 (32%) | 26 (30%) | 0.783 |
Medication | ||||
Platelet aggregation inhibitors† | 85 (57%) | 29 (48%) | 56 (62%) | 0.093 |
Anticoagulants | 30 (20%) | 11 (18%) | 19 (21%) | 0.667 |
Beta-blockers | 81 (54%) | 31 (52%) | 50 (56%) | 0.640 |
Statins | 87 (58%) | 37 (62%) | 50 (56%) | 0.458 |
ACE inhibitor or ARB | 57 (38%) | 19 (32%) | 38 (42%) | 0.192 |
Calcium channel blockers | 34 (23%) | 16 (27%) | 18 (20%) | 0.339 |
Loopdiuretics | 22 (15%) | 9 (15%) | 13 (14%) | 0.925 |
Nitroglycerin | 57 (38%) | 22 (37%) | 35 (39%) | 0.784 |
82Rb PET-CT findings | ||||
Rest LVEF | 58 (16) | 61 (17) | 57 (16) | 0.670 |
Stress LVEF | 61 (17) | 61 (17) | 69 (16) | 0.947 |
SDS | 4 (5) | 1 (2) | 6 (4) | <0.001 |
RPP | 11,024 (3068) | 10,341 (2258) | 11,501 (3458) | 0.227 |
Rest MBF uncorrected | 1.15 (0.38) | 1.12 (0.33) | 1.17 (0.42) | 0.511 |
Rest MBF corrected | 0.86 (0.25) | 0.89 (0.24) | 0.83 (0.25) | 0.170 |
Stress MBF | 2.41 (1.88) | 2.61 (0.77) | 2.28 (2.35) | 0.313 |
CFR | 3.19 (0.99) | 3 (1) | 3 (1) | 0.584 |
CAC results | ||||
0 | 8 (5%) | 5 (8%) | 3 (3%) | 0.038 |
1–100 | 27 (18%) | 17 (27%) | 10 (12%) | 0.007 |
101–300 | 26 (17%) | 14 (22%) | 12 (14%) | 0.043 |
>300 | 89 (59%) | 27 (43%) | 62 (71%) | <0.001 |
Continuous variables are presented as mean (SD), categorical variables as n(%). * P value for comparison between groups with and without obstructive CAD. CVD = cardiovascular disease, CAD = coronary artery disease, MI = myocardial infarction, PAD = peripheral artery disease. †Aspirin, clopidogrel or ticagrelor, LVEF = Left ventricular ejection fraction. SDS = Summed Difference Score [15], RPP = rate pressure product, MBF = myocardial bloodflow, CFR = Coronary flow reserve, CAC = Coronary Artery Calcium.