Fig. 1.

Typical cases in the DSHP dataset with single helix in three different binding modes, the one face (A), two face (B), and three face (C) modes. The corresponding PDB codes are (A) 1YDI, (B) 2WH6, and (C) 2BE6. Interacting profiles (white, blue, and red surfaces indicates interfacial carbon, nitrogen, and oxygen atoms, respectively) between helical ligands (purple cartoons) and the target proteins (green surfaces) were extracted from the complex structures. Predicted binding sites (red spheres in line) aligned well with the corresponding original helices. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)