Fig. 3.

Illustration of the HPer algorithm for helix binding position detection. (A) Definition of the principal axis and the principal plane of targeted atoms. (B) The helix axis is placed to mimic helix binding. (C) Rotation and translation of the helix axis for searching for positions with the best fitness score. (D) Interacting profile (red: negatively charged atoms and surface; blue: positively charged atoms and surface, white: hydrophobic atoms and surface) analysis around the potential helix binding site (red spheres). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)