Table 1.

Redesign of native helix-mediated protein-protein interactions. Binding energy and packing quality of designed models were calculated using Rosetta Scripts.

PDB_ID	Hot-spot residues Native/Designeda	Binding energy (REUb)	Packing quality
1VTY	Y437/W; W440/W; I441/V	−47.2	0.604
2GL7	L366/Null; I369/I; L373/Null	−15.0	0.610
2HWN	I8/I; I12/L; V16/A	−42.3	0.684
2P1L	L112/I; L116/L; F123/L	−57.7	0.634
2XA0	L59/E; L63/I; R64/R, I66/A; L70/L; M74/V	−61.2	0.608
2XZE	L210/L; M213/L; L217/W	−48.7	0.638
3H8K	L82/F; L89/V	−49.6	0.736
3KJ2	I6/L; I13/I; E17/Q	−56.0	0.632

^aThe corresponding designed residue type to each native hot-spot residue is given after the slash.

^bREU: Rosetta Energy Unit.