Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Naïve CD4+ T cells polarization and differentiation
| T cells subtype (transcription factor) | Effector cytokines | Polarization milieu | Dendritic cells subtype |
|---|---|---|---|
| Th1 (Tbet) | IFN-γ, IL-2, TNF-α | IL-12, IFN-γ, IL-18, IL-27 | Type 1 DC (DC1s) |
| Th2 (GATA3) | IL-4, IL-5, IL-13 | IL-4 | Type 2 DC (DC2s) |
| Tregs (FOXP3) | IL-10, TGF-β | IL-2, TGF-β, IL-27 | Regulatory DC (DCreg) |
