Fig. 12.

Synaptic processes and mitochondrial energy metabolism are enriched in metastable proteins. (A) Metastable subproteome enrichment ratio plotted against enrichment significance (p-value) for biological processes (left) and subcellular localisations (right). Point colours indicate the categories of the different processes, as in the legend of panel D (see also Tables S6–S7). (B) Metastable subproteome enrichment in specific subcellular localisations, categorized as in (A). Green shading coincides with subcellular localisations relevant to ion transport. (C) Enrichment ratio for the most significantly enriched biological processes (D) Chart showing the relative number of significantly enriched biological process categories, organized into the broad classifications indicated. *p < 0.05, **p < 0.01, ***p < 0.01, ****p < 0.001 and *****p < 0.0001 one tailed Fischer exact test and Bonferroni multiple hypothesis correction (Benjamini and Hochberg, 1995).