Fig. 14.

Distributions of Δ_B scores for tissues assigned to consecutive Braak stages, for a subset of genes downregulated in AD. Boxplots of the Δ_B scores for genes downregulated in AD, but not supersaturated nor downregulated in ageing. Boxplots are calculated for tissues progressively affected by AD (x-axis). For each boxplot, the significance of the difference with the prior Δ_B distribution for non-Braak (NB) tissues was calculated with a Mann-Whitney U test and Benjamini-Hochberg multiple hypothesis testing correction (Benjamini and Hochberg, 1995).