Fig. 5.

Distributions of Δ_B scores for tissues of consecutive Braak stages. (A) Boxplots of the Δ_B scores for the metastable subproteome calculated for ‘perfect match’ tissues (see Table S8) progressively affected by AD (x-axis). (B) Same data as for panel A, but for all tissues. A comparison of Δ_B score distributions is presented with white matter data included (left) and excluded from analysis (right). For each boxplot, the significance of the difference between Δ_B distributions for Braak I-III and Braak IV-VI datasets, and for Braak IV-VI and non- Braak (NB) datasets was calculated with a Mann-Whitney U test and Benjamini-Hochberg multiple hypothesis testing correction (Benjamini and Hochberg, 1995) *****p < 0.00001.