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. 2019 Sep 23;4(5):625–637. doi: 10.1016/j.jacbts.2019.05.007

Figure 5.

Figure 5

Cannabinoid 1 receptor Antagonist Attenuates the Binge Alcohol-Induced Vascular Changes

(A) Mean arterial blood pressure and total peripheral resistance measured after 3 h in control or in alcohol-binged mice before (ctrl base and EtOH base, respectively) and 15 min after intravenous rimonabant (Rimo) (ctlr + Rimo and EtOH + Rimo, respectively) administration. (B) Hindlimb microcirculation in control or in alcohol-binged mice before (ctrl base and EtOH base, respectively) and 15 min after intravenous Rimo. (C) Superior mesenteric artery and renal artery blood flow changes in control and in alcohol-binged mice before the treatment (ctrl base and EtOH base, respectively) and 15 min after intravenous Rimo (ctlr + Rimo and EtOH + Rimo, respectively) administration. Data are expressed as mean ± SEM, n = 5 to 7; *p < 0.05 vs. corresponding control group; #p < 0.05 vs. EtOH base group. CB1-R = cannabinoid 1 receptor; other abbreviations as in Figure 1.