Figure 8.

CB1-R Deletion Attenuates the Binge Alcohol Intoxication-Induced Cardiac Dysfunction

(A) Representative P-V loops of alcohol-binged CB1^+/+ and CB1^-/- mice after gradual preload reduction obtained by vena cava occlusion. Red lines indicate the slope of end-systolic P-V relationship, whereas blue lines show the slope of end-diastolic P-V relationship. (B) Load-independent indices of LV performance (Ees, the dP/dt_max – EDV relation, and PRSW) in control or in alcohol-binged CB1^+/+ and CB1^-/- mice. Data are expressed as mean ± SEM, n = 5 to 6; *p < 0.05 vs. corresponding control group; ^#p < 0.05 vs. alcohol-binged CB1^+/+ group. Abbreviations as in Figures 1, 2, 5, and 6.