Table 5.
Association analysis between SNPs and clinical biochemical data in patients with kidney stone.
| SNP | Genotype | Urine Creatinine (mg/dl) | Urine pH | UCa/UCra | UUA/UCrb | Serum Creatinine (mg/dl) | Serum Calcium (mg/dl) | Serum Uric Acid (mg/dl) |
|---|---|---|---|---|---|---|---|---|
| ALPLrs1256328 | TT | 71.2 ± 42.2 | 6.2 ± 0.9 | 0.2 ± 0.1 | 0.5 ± 0.2 | 1.4 ± 1.4 | 8.8 ± 0.5 | 6.2 ± 1.5 |
| CT | 87.6 ± 54.2 | 6.0 ± 0.6 | 0.1 ± 0.1 | 0.5 ± 0.2 | 1.2 ± 1.0 | 8.9 ± 0.6 | 6.5 ± 1.6 | |
| CC | 87.9 ± 58.6 | 6.0 ± 0.6 | 0.1 ± 0.1 | 0.5 ± 0.2 | 1.1 ± 0.8 | 8.9 ± 0.7 | 6.4 ± 1.8 | |
| P-value | 0.3634 | 0.1639 | 0.4293 | 0.9179 | 0.3790 | 0.3218 | 0.6075 | |
| Padj-value | 0.3362 | 0.1625 | 0.3798 | 0.9100 | 0.3558 | 0.3217 | 0.5633 | |
| CASRrs7627468 | GG | 95.1 ± 62.9 | 5.8 ± 0.6 | 0.1 ± 0.1 | 0.5 ± 0.2 | 1.2 ± 1.0 | 8.9 ± 0.7 | 6.4 ± 1.7 |
| AG | 90.0 ± 58.1 | 6.1 ± 0.7 | 0.1 ± 0.1 | 0.5 ± 0.2 | 1.1 ± 0.9 | 8.9 ± 0.6 | 6.4 ± 1.6 | |
| AA | 79.0 ± 49.0 | 6.1 ± 0.7 | 0.1 ± 0.1 | 0.5 ± 0.1 | 1.2 ± 0.9 | 9.0 ± 0.7 | 6.5 ± 1.9 | |
| P-value | 0.0921 | 0.0090 | 0.8526 | 0.8115 | 0.5804 | 0.4067 | 0.8801 | |
| Padj-value | 0.0739 | 0.0088 | 0.8319 | 0.7946 | 0.5616 | 0.4069 | 0.8633 | |
| RGS14rs12654812 | AA | 76.5 ± 44.2 | 5.9 ± 0.6 | 0.2 ± 0.1 | 0.5 ± 0.1 | 1.4 ± 1.4 | 9.0 ± 0.6 | 6.5 ± 2.1 |
| AG | 90.1 ± 58.0 | 6.1 ± 0.6 | 0.1 ± 0.1 | 0.5 ± 0.2 | 1.1 ± 0.6 | 8.9 ± 0.6 | 6.3 ± 1.7 | |
| GG | 86.8 ± 57.2 | 6.0 ± 0.7 | 0.1 ± 0.1 | 0.5 ± 0.2 | 1.2 ± 1.0 | 8.9 ± 0.7 | 6.5 ± 1.7 | |
| P-value | 0.4383 | 0.3600 | 0.0764 | 0.9605 | 0.1729 | 0.6411 | 0.7895 | |
| Padj-value | 0.4109 | 0.3582 | 0.0532 | 0.9568 | 0.1556 | 0.6410 | 0.7623 |
aUrinary calcium-to-creatinine ratio (UCa/UCr). bUrinary uric acid-to-creatinine ratio (UUA/UCr). P values which remain significant after performing Bonferroni correction (p ≤ 0.016) are shown in bold. The Padj value was adjusted for gender and age.