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(A) Sequence similarity network generated from the Bmp8 amino acid sequence. Some clusters have been labeled with colocalized enzymes or putative functions. Bmp8 and PLCMD are indicated with a black outline in the bromopyrrole and RecJ/OsmC clusters, respectively. (B) Weblogo analysis of 1000 Bmp8 homologues. Residues in red were mutated, and the resulting Bmp8 variant was tested for activity (Figure 2B). Residues are numbered according to the Bmp8 sequence.
