Mucocutaneous	Pulmonary hemorrhage	Hematologic
Malar rash	Shrinking lung syndrome	Vascular thrombosis
Discoid rash	Gastrointestinal	Hemolytic anemia
Subacute cutaneous LE	Peritonitis	Direct coomb’s test
Bullous skin lesions	Pancreatitis	Antiphospholipid syndrome (APS)
Panniculitis	Hepatitis	Leukopenia
Alopecia	Renal	Lymphopenia
Cutaneous vasculitis	Dialysis	Thrombocytopenia
Raynaud’s	Renal transplantation	Serologies
Livedo reticularis	Lupus nephritis	Lupus anticoagulant
Urticaria	24 hour urine for protein (≥ 500mg)	Anticardiolipin antibodies
Photosensitivity	Urine protein/creatinine > 0.5	Anti-beta 2 glycoprotein I
Mucosal ulcers	Urine protein/creatinine > 3	Low C3
Chilblain lupus	Urinalysis: protein	Low C4
Lupus tumidus	Urinalysis: cellular casts	Low complement
LE mucosus	Musculoskeletal	ANA
Maculopapular rash	Arthritis	Anti-ds DNA
Toxic epidermal necrolysis	Jaccoud’s arthropathy	Anti-Smith
Serositis	Avascular necrosis	Anti-Smith/RNP
Serositis	Myositis	Anticardiolipin (aCL) antibodies (IgG)
Pleuritis	Neurological	Anticardiolipin (aCL) antibodies (IgM)
Pericarditis	Seizures	Anti-beta2 glycoprotein I-IgG
Peritonitis	Psychosis	Anti-beta2 glycoprotein I-IgM
Cardiovascular	Mononeuritis multiplex	Anticoagulant screen confirmatory test
Pericarditis	Cerebrovascular disease	Anti-RNP
Myocardial infarction	Transverse myelitis	Anti-Ro/SSA
Pulmonary	Aseptic meningitis	Anti-La/SSB
Pulmonary hypertension	Chorea	RF
Interstitial lung disease	Cranial and/or peripheral neuropathy	Antiphospholipid (aPL) antibodies
Pneumonitis	Acute confusional state	Lupus anticoagulant confirmatory