Table 2.

Cox regression of dementia diagnosis among men (n = 89,251) and women (n = 66,853) with atrial fibrillation HR and with or without levothyroxine treatment

	Model 1		Model 2		Model 3		Model 4
	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI
Men
Levothyroxine treatment	1.04	0.89–1.22	1.03	0.87–1.20	1.01	0.86–1.19	1.01	0.86–1.19
No treatment	Ref		Ref		Ref		Ref
Women
Levothyroxine treatment	1.07	0.98–1.16	1.04	0.96–1.14	1.04	0.96–1.13	1.04	0.95–1.13
No treatment	Ref		Ref		Ref		Ref
Alla
Levothyroxine treatment	1.07	0.99–1.15	1.04	0.97–1.12	1.03	0.96–1.12	1.03	0.96–1.11
No treatment	Ref		Ref		Ref		Ref

Model 1 adjusted for age, Model 2 adjusted for age, educational level, immigrant status, marital status, and neighborhood deprivation, Model 3 Model 2 + comorbidities, Model 4 Model 3 + cardiovascular medications

^aGender was added in the Model 2, Model 3, and Model 4