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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2019 Aug 16;105(5):1119–1125. doi: 10.1016/j.ijrobp.2019.08.011

Fig. 1.

Fig. 1.

(A) Clonogenic cell survival curves of isogenic pairs of HT1080 cells that are either proficient in HR or deficient in HR (HT1080-shRAD51IND) exposed to photons or 7.3 keV/μm protons after doxycycline treatment. (B) Clonogenic cell survival curves of isogenic pairs of HT1080 cells that are either NHEJ-proficient (HT1080) or -deficient (HT1080-shDNA-PKcs) exposed to photons or to high-LET protons after doxycycline treatment. (C) D10% from the clonogenic survival curves of HT1080, HT1080-shRAD51IND, and HT1080-shDNA-PKcs cells after exposure to photons or protons at three LET values. Inset, western blots to confirm depletion of RAD51 expression after doxycycline treatment (Supplemental Method 7). (D) Sensitization relative to wild-type (WT) (DNA repair-proficient) cells exposed to photons. Note that for comparison and visualization the HT1080 photon data is repeated in A and B.