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. 2019 Nov 15;13:1223. doi: 10.3389/fnins.2019.01223

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Copyright © 2019 Gao, Zhuang, Lu, Tao, Zhou, Liu, Wang, Zhang, Wu, Dai, Li and Hang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of curcumin (cur) on expression of toll-like receptor 4 (TLR4) and neuroprotection, evaluated by brain water content, neurological score, and TUNEL staining at 24 h after SAH. (A) Curcumin with 100 mg/kg significantly reduced the protein level of TLR4 at 24 h post SAH. (B,C) Curcumin treatment ameliorated the brain water content and neurological function at 24 h after SAH as compared with the SAH + vehicle group. (D) Representative immunofluorescence staining images of TUNEL (NeuN = green, TUNEL = red, DAPI = blue) (E) Administration of curcumin remarkably decreased the amount of TUNEL-positive neurons at 24 h after SAH compared with the SAH + vehicle group. The quantitative data are the mean ± SD [n = 5, each; ^∗p < 0.05, ^∗∗p < 0.01 vs. SAH group, Sham + Cur group; ^#p < 0.05 vs. SAH + Cur (50 mg/kg) group, SAH + Vehicle group; ^nsp > 0.05]. Scale bars = 50 μm.