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. 2019 Nov 15;13:1223. doi: 10.3389/fnins.2019.01223

FIGURE 5.

FIGURE 5

Effects of curcumin treatment on microglia polarization at 24 h after SAH. (A,D) Representative immunofluorescence staining images of M1 (Iba-1+/CD86+, Iba-1 = green, CD86 = red) and M2 (Iba-1+/CD206+, Iba-1 = green, CD86 = red). Amplification images of phenotype M1 and M2 shown in white box of all groups. (B,E) Quantification showed that curcumin treatment reduced the elevated proportion of M1 (Iba-1+/CD86+), and further elevated the amount of M2 (Iba-1+/CD206+) at 24 h after SAH compared with the SAH + vehicle group. (C,F) Curcumin administration decreased the protein level of CD86 and increased the expression of CD206 as compared with the SAH + vehicle group at 24 h after SAH. The quantitative data are the mean ± SD (n = 8, each; ∗p < 0.05, ∗∗p < 0.01 vs. Sham + Cur group; #p < 0.05 vs. SAH + Vehicle group; nsp > 0.05). Scale bars = 50 μm.