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. 2019 May 3;115(14):1986–1997. doi: 10.1093/cvr/cvz111

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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.

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Differentially regulated genes in cMyBP-C^ΔC10mut compared with NTG hearts. (A) RNA-seq heat maps depicting clusters of genes differentially regulated in cMyBP-C^ΔC10mut vs. NTG hearts. Shown is a subset of the most up-regulated (red) and down-regulated (green) genes from the total gene set. The fold change, up or down, is represented in the key for the respective panels (n = 4 pooled samples per genotype). (B) Network of significantly enriched gene ontology terms for upregulated genes in cMyBP-C^ΔC10mut hearts. The red and green circles denote upregulated and downregulated genes, respectively, in cMyBP-C^ΔC10mut compared with NTG hearts. Blue rectangles represent significantly enriched (P < 0.05; FDR) biological processes using the ToppFun application of ToppGene Suite.