Comparison 4. Quality of Life.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 FACT‐G QoL	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 FACT‐G at 6 months	1	168	Mean Difference (IV, Fixed, 95% CI)	‐2.5 [‐5.80, 0.80]
1.2 FACT‐G QoL at 12 months	2	685	Mean Difference (IV, Fixed, 95% CI)	‐0.52 [‐2.31, 1.26]
2 FACT‐C QoL	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
2.1 FACT‐C at 3 months	1	18	Mean Difference (IV, Random, 95% CI)	14.0 [2.87, 25.13]
3 FACT‐B QoL	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 FACT‐B at 3 months	1	23	Mean Difference (IV, Fixed, 95% CI)	15.60 [‐4.96, 36.16]
3.2 FACT‐B at 6 months	1	90	Mean Difference (IV, Fixed, 95% CI)	4.90 [‐0.80, 10.60]
4 SF‐36 QoL physical function score	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
4.1 SF‐36 QoL at 6 months	1	168	Mean Difference (IV, Random, 95% CI)	2.20 [‐4.62, 9.02]
4.2 SF‐36 QoL at 12 months	1	160	Mean Difference (IV, Random, 95% CI)	‐0.20 [‐7.42, 7.02]
5 SF‐36 QoL mean change physical	4		Mean Difference (IV, Random, 95% CI)	Subtotals only
5.1 SF‐36 at 6 months	2	500	Mean Difference (IV, Random, 95% CI)	‐0.15 [‐1.59, 1.28]
5.2 SF‐36 at 12 months	3	1091	Mean Difference (IV, Random, 95% CI)	1.91 [0.45, 3.37]
6 SF‐36 QoL mean change mental	3		Mean Difference (IV, Random, 95% CI)	Subtotals only
6.1 SF‐36 mean change at at 6 months	1	410	Mean Difference (IV, Random, 95% CI)	0.7 [‐0.96, 2.36]
6.2 SF‐36 mean change at 12 months	3	1091	Mean Difference (IV, Random, 95% CI)	‐0.11 [‐3.29, 3.08]
7 SF‐36 QoL mean change mental for each cancer site at 12 months	3		Mean Difference (IV, Random, 95% CI)	Subtotals only
7.1 Breast cancer	1	40	Mean Difference (IV, Random, 95% CI)	‐4.3 [‐9.69, 1.09]
7.2 Colorectal cancer	1	410	Mean Difference (IV, Random, 95% CI)	‐0.7 [‐2.64, 1.24]
7.3 Breast, colorectal, and prostate cancer	1	641	Mean Difference (IV, Random, 95% CI)	7.04 [5.25, 8.83]
8 Cancer‐related fatigue	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
8.1 Cancer‐related fatigue at 6 months	1	410	Mean Difference (IV, Fixed, 95% CI)	1.4 [‐0.26, 3.06]
8.2 Cancer related fatigue at 12 months	1	410	Mean Difference (IV, Fixed, 95% CI)	1.0 [‐0.81, 2.81]
9 Global QoL questionnaire	3		Mean Difference (IV, Random, 95% CI)	Subtotals only
9.1 Global QoL at 3 months	2	220	Mean Difference (IV, Random, 95% CI)	4.71 [2.22, 7.21]
9.2 Global QoL at 6 months	1	80	Mean Difference (IV, Random, 95% CI)	33.97 [28.97, 38.97]
9.3 Global QoL at 12 months	1	174	Mean Difference (IV, Random, 95% CI)	4.80 [‐0.79, 10.39]