Table 1.
Characteristics of intermediate-stage patients classified as Child-Pugh class A
| Total (n = 1,306) | Tumor marker score 0 (n = 296) | Tumor marker score 1 (n = 434) | Tumor marker score ≥2 (n = 576) | p value | |
|---|---|---|---|---|---|
| Age, years3 69.4 (9.0) | 69.4 (8.7) | 69.3 (8.5) | 69.5 (9.5) | 0.982b | |
| Etiology (HCV:HBV:HBV&HCV: NBNC:unknown) | 901:150:20:230:5 | 208:33:2:51:2 | 291:45:9:88:1 | 402:72:9:91:2 | 0.426c |
| Total-bilirubin, mg/dLa | 0.87 (0.38) | 0.91 (0.37) | 0.89 (0.39) | 0.89 (0.39) | 0.639b |
| Albumin, g/dLa | 3.77 (0.42) | 3.78 (0.39) | 3.77 (0.42) | 3.76 (0.42) | 0.768b |
| Prothrombin time, %a | 86.3 (12.9) | 85.8 (12.5) | 86.1 (13.3) | 86.7 (12.8) | 0.607b |
| Child-Pugh score (5:6) | 801:505 | 179:117 | 262:172 | 360:216 | 0.743c |
| Maximum tumor size, cma | 4.75 (3.77) | 3.84 (4.05) | 4.86 (3.79) | 5.13 (3.52) | <0.001b |
| Up-to-7 criteria (within:beyond) | 418:888 | 129:167 | 130:304 | 159:417 | 0.002c |
| AFP ≥100 ng/mL | 546 (41.8%) | 0 (0%) | 72 (16.6%) | 474 (82.3%) | <0.001c |
| AFP-L3 ≥10% | 528 (40.4%) | 0 (0%) | 64 (14.7%) | 464 (80.6%) | <0.001c |
| DCP ≥100 mAU/mL | 787 (60.3%) | 0 (0%) | 298 (68.7%) | 489 (84.9%) | <0.001c |
| MST, years | 4.0 | 4.8 | 3.8 | 3.2 | <0.001d |
HCV, hepatitis C virus; HBV, hepatitis B virus; NBNC, negative for both HBV and HCV; AFP, alpha-fetoprotein; AFP-L3, fucosylated AFP; DCP, des-gamma-carboxy prothrombin; MST, median survival time.
a
Values shown as the mean (standard deviation).
b
One-way ANOVA.
c
Kruskal-Wallis test.
d
log-rank test.