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Influence of exercise and inflammation on the kynurenine pathway. Thin colored arrows represent an acute effect and bold colored arrows represent a long-term effect. IDO: Indoleamine-2,3-Dioxygenase; IFN: interferon [IFN]-γ; IL6: interleukin 6; TDO: Tryptophan-2,3-Dioxygenase; TNFα: Tumor necrosis factor α; Tcytotox: cytotoxic T cells; Thelper: T helper cells; Treg: regulatory T-cells.
