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IPA competition for Sec18 binding and function
mSec18 is monomeric Sec18; hSec18 is hexameric Sec18; Lip. is liposomes; NA is not applicable.
| Analyte | Ligand | Competitor | Method | IC50 |
|---|---|---|---|---|
| mSec18 | 5% PA Lip. 8 μm | IPA | SPR | 762 nm |
| D1 | 5% PA Lip. 8 μm | IPA | SPR | 220 nm |
| D2 | 5% PA Lip. 8 μm | IPA | SPR | 641 nm |
| mSec18 | Sonicated Lip. | IPA | Lip. floatation | 3 μm |
| NA | Isolated vacuoles | IPA | Fusion | 50 μm |
| NA | hSec18 | IPA | Fusion priming | 50 μm |
